Dose-related Adverse Reactions: Spontaneously generated unfavorable reaction data from a research of schizophrenia contrasting five set dosages of Seroquel (75 milligrams, 150 milligrams, 300 mg, 600 milligrams, as well as 750 mg/day) to placebo were explored for dose-relatedness of unfavorable responses. Logistic regression evaluations exposed a good dosage feedback (p<0.05) for the following adverse reactions: dyspepsia, abdominal pain, and weight gain.
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The following adverse reactions have also been reported with quetiapine: nightmares, hypersensitivity and elevations in serum creatine phosphokinase (not associated with NMS), galactorrhea, bradycardia (which may occur at or near initiation of treatment and be associated with hypotension and/ or syncope), decreased platelets, somnambulism (and other related events), elevations in gamma-GT levels, hypothermia, and priapism.
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Class Effect: Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. Dystonic symptoms include: spasm of the neck muscles, sometimes progressing to tightness of the throat, swallowing difficulty, difficulty breathing, and/or protrusion of the tongue. While these symptoms can occur at low doses, they occur more frequently and with greater severity with high potency and at higher doses of first generation antipsychotic drugs. An elevated risk of acute dystonia is observed in males and younger age groups.